2. Neuronal Signaling Membrane Transporter/Ion Channel Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  3. Calcium Channel Reactive Oxygen Species Apoptosis Endogenous Metabolite
  4. L-Ascorbic acid sodium salt

L-Ascorbic acid sodium salt  (Synonyms: 维生素C钠; Sodium ascorbate; Sodium L-ascorbate; Vitamin C sodium salt)

目录号: HY-B0166A 纯度: 99.17%
COA 产品使用指南

摩尔计算器

L-Ascorbic acid sodium salt (Sodium ascorbate)，一种电子供体，是一种内源性抗氧化剂。L-Ascorbic acid sodium salt 选择性抑制 Cav3.2 通道 (Cav3.2 channels)，IC50 为 6.5 μM。L-Ascorbic acid sodium salt 还是一种胶原沉积促进剂和弹性生成抑制剂。

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L-Ascorbic acid sodium salt Chemical Structure

L-Ascorbic acid sodium salt Chemical Structure

CAS No. : 134-03-2

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规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥500
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500 mg ￥400
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1 g ￥500
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5 g ￥1000
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10 g ￥1500
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50 g   询价  

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Customer Review

Other Forms of L-Ascorbic acid sodium salt:

L-Ascorbic acid sodium salt 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 46 篇科研文献

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

L-Ascorbic acid sodium salt (Sodium ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt selectively inhibits Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3].

IC50 & Target

T-type calcium channel

 

Microbial Metabolite

 

Human Endogenous Metabolite

 

体外研究
(In Vitro)

The conditioned medium for B16F10 cells significantly inhibits cell apoptosis induced by L-Ascorbic acid sodium salt (Sodium L-ascorbate) (10 mM), and the effective ingredients in the medium show a relative molecular mass below 5,000[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

L-Ascorbic acid sodium salt 相关抗体:
体内研究
(In Vivo)

Tg rats treated with L-Ascorbic acid sodium salt (Sodium L-ascorbate) show a higher incidence of carcinoma (29.6%), compared to those without L-Ascorbic acid sodium salt (15.4%). Independent of the L-Ascorbic acid sodium salt treatment, transgenic rats exhibit various kinds of malignant tumors in various organs[5].
After 12 weeks of PEITC-treatment, both simple hyperplasia and papillary or nodular (PN) hyperplasia have developed in all animals, but the majority of these lesions have disappeared at week 48, irrespective of the L-Ascorbic acid sodium salt-treatment. The same lesions after 24 weeks of PEITC-treatment have progressed to dysplasia and carcinoma, in a small number of cases by week 48, but enhancement by the L-Ascorbic acid sodium salt-treatment is evident only with simple hyperplasias and PN hyperplasias in rats[6].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

198.11

Formula

C6H7NaO6
CAS 号
性状

固体

颜色

Off-white to light yellow

中文名称

L-抗坏血酸钠；维生素C钠
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 100 mg/mL (504.77 mM; 超声助溶)

DMSO 中的溶解度 : 1 mg/mL (5.05 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.0477 mL 25.2385 mL 50.4770 mL
5 mM 1.0095 mL 5.0477 mL 10.0954 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： PBS

    Solubility: 50 mg/mL (252.39 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.97%

COA (292 KB) HNMR (115 KB) RP-HPLC (338 KB)

产品使用指南 (1538 KB)
参考文献
Animal Administration
[3]

A total of 40 7-week-old male Tg rats are divided into 2 groups. Twenty-seven (group 1) and 13 (group 2) rats are given a powdered MF diet with or without 5% sodium L-ascorbate, respectively. Similarly, a total of 42 7-week-old male Non-tg rats are divided into 2 groups, and 30 (group 3) and 12 (group 4) animals are given a diet with or without 5% sodium L-ascorbate, respectively.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

L-Ascorbic acid sodium salt 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 5.0477 mL 25.2385 mL 50.4770 mL 126.1925 mL
5 mM 1.0095 mL 5.0477 mL 10.0954 mL 25.2385 mL
H2O 10 mM 0.5048 mL 2.5239 mL 5.0477 mL 12.6193 mL
15 mM 0.3365 mL 1.6826 mL 3.3651 mL 8.4128 mL
20 mM 0.2524 mL 1.2619 mL 2.5239 mL 6.3096 mL
25 mM 0.2019 mL 1.0095 mL 2.0191 mL 5.0477 mL
30 mM 0.1683 mL 0.8413 mL 1.6826 mL 4.2064 mL
40 mM 0.1262 mL 0.6310 mL 1.2619 mL 3.1548 mL
50 mM 0.1010 mL 0.5048 mL 1.0095 mL 2.5239 mL
60 mM 0.0841 mL 0.4206 mL 0.8413 mL 2.1032 mL
80 mM 0.0631 mL 0.3155 mL 0.6310 mL 1.5774 mL
100 mM 0.0505 mL 0.2524 mL 0.5048 mL 1.2619 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Ascorbic acid134-03-2Sodium ascorbate Sodium L-ascorbateVitamin CL-抗坏血酸钠维生素C钠Calcium ChannelReactive Oxygen SpeciesApoptosisEndogenous MetaboliteCa2+ channelsCa channelsInhibitorinhibitorinhibit

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